Tag Archives: genes

Music affects on the brain

A recent paper identified genes that changed their expression as a result of music performance in trained musicians. (see citation below). There were a surprising number of affected genes, 51 genes had increased and 22 had decreased expression, compared to controls who were also trained musicians but were not involved in making or listening to music for the same time period. It is also impressive that this set of 73 genes has a very broad range of presumed functions and effects in the brain.

musictableAnother interesting aspect is the overlap of a number of these genes with some that have been identified in song birds. This implies that the music/sophisticated sound perception and production has been conserved from a common ancestor of birds and mammals.

It has been known for some time that musical training has a positive effect on intelligence and outlook – that it assists learning. Musical training changes the structure of the brain. Now scientists are starting to trace the biology of music’s effects. Isn’t it about time that education stopped treating music (and other arts for that matter) as unimportant frills? It should not be the first thing to go when money or teaching time is short.

Here is the Abstract:

Music performance by professional musicians involves a wide-spectrum of cognitive and multi-sensory motor skills, whose biological basis is unknown. Several neuroscientific studies have demonstrated that the brains of professional musicians and non-musicians differ structurally and functionally and that musical training enhances cognition. However, the molecules and molecular mechanisms involved in music performance remain largely unexplored. Here, we investigated the effect of music performance on the genome-wide peripheral blood transcriptome of professional musicians by analyzing the transcriptional responses after a 2-hr concert performance and after a ‘music-free’ control session. The up-regulated genes were found to affect dopaminergic neurotransmission, motor behavior, neuronal plasticity, and neurocognitive functions including learning and memory. Particularly, candidate genes such as SNCA, FOS and DUSP1 that are involved in song perception and production in songbirds, were identified, suggesting an evolutionary conservation in biological processes related to sound perception/production. Additionally, modulation of genes related to calcium ion homeostasis, iron ion homeostasis, glutathione metabolism, and several neuropsychiatric and neurodegenerative diseases implied that music performance may affect the biological pathways that are otherwise essential for the proper maintenance of neuronal function and survival. For the first time, this study provides evidence for the candidate genes and molecular mechanisms underlying music performance.”


Kanduri, C., Kuusi, T., Ahvenainen, M., Philips, A., Lähdesmäki, H., & Järvelä, I. (2015). The effect of music performance on the transcriptome of professional musicians Scientific Reports, 5 DOI: 10.1038/srep09506

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